This article discusses the research that combined two over-the-counter substances, Bromelain and NAC. The resulting mix called BromAc can break the bonds that keep the spike protein of the SARS-CoV-2 virus together.
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The study The Combination of Bromelain and Acetylcysteine (BromAc) Synergistically Inactivates SARS-CoV-2 was done in Australia and France. One of the lead authors is associated with Mucpharm in Sydney, Australia, which makes BromAc.
Severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection is the cause of a worldwide pandemic, currently with limited therapeutic options. The spike glycoprotein and envelope protein of SARS-CoV-2, containing disulfide bridges for stabilization, represent an attractive target as they are essential for binding to the ACE2 receptor in host cells present in the nasal mucosa. Bromelain and Acetylcysteine (BromAc) has synergistic action against glycoproteins by breakage of glycosidic linkages and disulfide bonds. We sought to determine the effect of BromAc on the spike and envelope proteins and its potential to reduce infectivity in host cells. Recombinant spike and envelope SARS-CoV-2 proteins were disrupted by BromAc. Spike and envelope protein disulfide bonds were reduced by Acetylcysteine. In in vitro whole virus culture of both wild-type and spike mutants, SARS-CoV-2 demonstrated a concentration-dependent inactivation from BromAc treatment but not from single agents.
So, clearly this is VERY good news. If we can literally DISSOLVE the Spike Protein before it interacts with our ACE2 (and clearly many other) receptors, then the Spike, in essence, becomes as the nonillions of other viruses on the planet that cannot enter our cells.
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https://doi.org/10.3390/v13030425.
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Related:
https://doi.org/10.1155/2015/918089.
Research Journal.
https://doi.org/10.22074/cellj.2016.4872.
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https://doi.org/10.3389/fphar.2021.717757.
Research Journal.