The invention belongs to the field of nano materials and biomedicine, and relates to a vaccine, in particular to development of 2019-nCoV coronavirus nuclear recombinant nano vaccine. The invention also comprises a preparation method of the vaccine and application of the vaccine in animal experiments. The new corona vaccine contains graphene oxide, carnosine, CpG and new corona virus RBD; binding carnosine, CpG and neocoronavirus RBD on the backbone of graphene oxide; the CpG coding sequence is shown as SEQ ID NO 1; the novel coronavirus RBD refers to a novel coronavirus protein receptor binding region which can generate a high-titer specific antibody aiming at the RBD in a mouse body, and provides a strong support for prevention and treatment of the novel coronavirus.
Sources:
- January 15, 2021. 崔大祥, 高昂, 梁辉, 田静, 李雪玲, and 沈琦. Nano coronavirus recombinant vaccine taking graphene oxide as carrier. China CN112220919A, filed September 27, 2020, and issued January 15, 2021. Assignee: Shanghai National Engineering Research Center for Nanotechnology Co Ltd.
https://patents.google.com/patent/CN112220919A/en,
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