The present invention provides a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or more of non-structural protein(s) (nsp)-10, nsp-14, nsp-15 or nsp-16. The coronavirus may be used as a vaccine for treating and/or preventing a disease, such as infectious bronchitis, in a subject.
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Related:
- October 28, 2019. Kelly Davio. “NIH, Bill and Melinda Gates Foundation Collaborate to Develop Gene-Based HIV Treatment.” The American Journal of Managed Care.
https://www.ajmc.com/view/nih-bill-and-melinda-gates-foundation-collaborate-to-develop-genebased-hiv-treatment.
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