Pandemic Timeline

Tag: National Institute of Allergy and Infectious Diseases

UNC Chapel Hill files patent US7279327: Methods for producing recombinant coronavirus

A helper cell for producing an infectious, replication defective, coronavirus (or more generally nidovirus) particle cell comprises (a) a nidovirus permissive cell; (b) a nidovirus replicon RNA comprising the nidovirus packaging signal and a heterologous RNA sequence, wherein the replicon RNA further lacks a sequence encoding at least one nidovirus structural protein; and (c) at…

Sequoia Pharmaceuticals files patent US7151163: Antiviral agents for the treatment, control and prevention of infections by coronaviruses

The invention provides compositions and methods that are useful for preventing and treating a coronavirus infection in a subject. More specifically, the invention provides peptides and conjugates and pharmaceutical compositions containing those peptides and conjugates that block fusion of a coronavirus, such as the SARS virus, to a target cell. This blocking mechanism prevents or…